USA vs Uruguay prediction, H2H and probable lineups - November 19, 2025

USA vs Uruguay prediction Photo: dazn.com / Author unknown
Finished
5 : 1
International,
Sebastian Berhalter
17'
Alex Freeman
21' 32'
Diego Luna
43'
Tanner Tessmann
69'
45'
Giorgian De Arrascaeta

One of the friendlies of this international break will take place on Wednesday at the Raymond James Stadium in Florida, where the USA will host Uruguay. I’m offering a bet on the outcome of this clash with strong chances for success.

Match preview

The US national team is determined to finish the year on a high note, and an ongoing four-game unbeaten streak fuels that optimism. Under Mauricio Pochettino, the squad is adapting to a new playing style and has finally started to showcase a systematic brand of football. Wins over Japan, Australia, and Paraguay, along with a draw against Ecuador, reflect growing self-belief.

The current American roster is weakened by the absence of several key players, but this has opened the door for the reserves to step up. Giovanni Reyna has already seized his chance, netting an early goal against Paraguay and injecting new life into the attack. The combination of Reyna, Balogun, and Aaronson up front looks promising, while the midfield pairing of Morris and Tessmann brings fresh energy and pressing intensity.

Uruguay breezed through South American qualifiers, securing a direct World Cup spot and beating giants like Argentina and Brazil along the way. Marcelo Bielsa’s side plays disciplined, high-intensity football focused on physicality and compactness. Since the Argentine took over as head coach in 2023, Uruguay has lost just six times.

However, significant personnel losses complicate Uruguay’s task in this upcoming match. Without Valverde and Núñez, their attack loses bite, and the defense may be forced to reshuffle. The potential inclusion of youngsters like Homenchenko or Pellistri could liven up the flanks, but midfield chemistry and creativity will be under scrutiny.

Probable lineups

  • USA: Freese, Robinson, Ream, Trusty, Dest, Morris, Tessmann, Arfsten, Aaronson, Balogun, Reyna
  • Uruguay: Mele, Varela, Giménez, Araújo, Piqueréz, Bentancur, Ugarte, De Arrascaeta, Torres, Aguirre, Pellistri

Match facts and head-to-head

  • The USA’s last win over Uruguay came in 2002.
  • Uruguay is unbeaten in its last six matches.
  • In their most recent meeting at Copa América 2024, Uruguay won 1-0.

Prediction

Despite being a friendly, both teams view this encounter as a crucial step in their preparations for the 2026 World Cup. Both sides will be without several key performers, leveling the playing field. The USA tends to play with more boldness and aggression at home, but Uruguay knows how to adapt and maintain tempo. Expect a tight, organized contest where neither side will want to give an inch.

Prediction on game Total under 2.5
Odds: 1.66
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