The hosts must end their European slump: Inter vs Shakhtar prediction

Inter vs Shakhtar Donetsk prediction Photo: dazn.com / Author unknown
Champions League (Round 3) 21 oct 2026, 15:00
- : -
International, Milano, Giuseppe Meazza

The third-round league-phase clash between Inter and Shakhtar in the Champions League will take place on October 21, 2026, at the Giuseppe Meazza Stadium. The Milan side have lost both of their opening matches and remain without a point, while the Ukrainian club have collected four points. At the same time, both teams have been performing with great confidence in their domestic leagues, so the meeting in Milan promises to be far more challenging for the favorite than the teams' respective statuses might suggest.

Inter: it is time to take their domestic form to Europe

Christian Chivu's team have been experiencing serious problems specifically in the Champions League. After losing 2-1 to Real Madrid, the Milan side fell 4-3 to Club Brugge, despite Lautaro Martínez scoring twice. Moreover, Inter have lost seven of their last eight matches in Europe's premier club competition, a stark contrast to their Serie A results that only increases the pressure ahead of the home fixture.

The situation is much calmer in the domestic league: Inter are among the leaders and have dropped just two points after seven rounds. In their latest match, the Milan side defeated Bologna 3-1, once again managing to come from behind. The main injury concern is Lautaro Martínez, so Pio Esposito or Ange-Yoan Bonny should start alongside Marcus Thuram in attack.

Shakhtar: confident form and positive European momentum

Arda Turan's team remain unbeaten in the current league phase. First, Shakhtar drew 1-1 with PSV, then defeated AEK 3-1, turning the match around after conceding the opening goal. Pedrinho, Vinicius Tobias and Gleyker Mendoza found the net, while the team itself showed that it can punish opponents effectively for mistakes in transition.

Their overall form is impressive as well: Shakhtar are unbeaten in eight consecutive matches and sit top of the Ukrainian league. However, their record against Italian clubs is far weaker — the Ukrainians have failed to win any of their last ten meetings with Serie A sides and did not score in nine of them. In addition, Shakhtar have never beaten Inter in their previous seven encounters, scoring just once.

Match facts and head-to-head record

  • Inter have lost both of their opening matches in this season's Champions League.
  • Shakhtar are unbeaten in eight consecutive competitive matches.
  • The Ukrainian club have never beaten Inter in their previous seven head-to-head meetings.

The hosts' class should tell: Inter vs Shakhtar prediction

Shakhtar come into the match in good shape and are more than capable of causing problems for the hosts, especially if they are given space to launch quick attacks. The Ukrainians have already proved that they know how to capitalize on opponents' mistakes and maintain a high tempo throughout the game, so their scoring cannot be ruled out entirely.

However, Inter are too strong at home and must respond to their poor start in Europe. Despite Lautaro's absence, the depth of their squad and their current Serie A form should be enough to control most of the match and finally end their losing streak in the Champions League.

Prediction on game W2(+2.0)
Odds: 1.97
Mostbet Bonus up to €3 000 + 445 FS
Mostbet
4.95
View odds
Comments
Only registered users can post and reply to comments
Upcoming Predictions
Inter
Inter vs Shakhtar Donetsk prediction Champions League Can Shakhtar punish a vulnerable Inter defense? Inter vs Shakhtar prediction | October 21, 2026 Inter Odds: 1.75 Shakhtar Donetsk Recommended Mostbet
Champions League
Lille vs Galatasaray prediction Champions League Time to emerge from the crisis. Lille vs Galatasaray prediction Lille Odds: 1.57 Galatasaray View odds BC.Game
Champions League
Como vs Manchester United prediction Champions League The English side can end their winless streak: Como vs. Manchester United prediction Como Odds: 1.84 Manchester United View odds Mostbet
Champions League
Lille vs Galatasaray prediction Champions League Home advantage could prove decisive: Lille vs. Galatasaray prediction Lille Odds: 1.6 Galatasaray Recommended BC.Game
Champions League
Bayern Munich vs Arsenal prediction Champions League Bayern vs Arsenal: a clash of giants where any mistake could prove decisive Bayern Munich Odds: 1.48 Arsenal View odds Mostbet
Champions League
Aston Villa vs Viking prediction Champions League Which Team Will Extend Its Unbeaten Run? Aston Villa vs Viking Prediction | October 21, 2026 Aston Villa Odds: 1.83 Viking Recommended BC.Game
Ghazl Al Mahalla vs Al Ittihad Alexandria prediction Premier League Egypt Ghazl El Mahalla vs Al Ittihad: Prediction, stats, betting tips and H2H – October 21, 2026 Ghazl Al Mahalla Odds: 1.58 Al Ittihad Alexandria Recommended Mostbet
Al Ahly SC vs Olympic El Qanah FC prediction Premier League Egypt Al Ahly vs Al Qanah: can the bold newcomers stop the hosts’ title-chasing momentum? Al Ahly SC Odds: 1.71 Olympic El Qanah FC View odds BC.Game
Daily Sports News, Predictions and Live Scores