Cagliari vs Pisa prediction, H2H and probable lineups - December 21, 2025
One of the key fixtures of Serie A's 16th round will unfold this Sunday at the Unipol Domus in Cagliari, where the home side will welcome Pisa. Both teams are locked in a fierce battle for survival and find themselves in the relegation zone danger. Here’s a bet on the outcome of this clash with solid winning potential.
Match preview
Cagliari are enduring a tough spell in the league — just one win in their last 11 matches, and that came against Roma at home. Gianluca Gaetano netted the winner against the Romans. He also found the back of the net in the previous round against Atalanta, but this time Cagliari fell short.
The team crashed out of the Coppa Italia after losing to Napoli on penalties and is now fully focused on Serie A. This final home match of 2025 is a golden opportunity to claim three points and strengthen their position above the drop zone. Considering Cagliari haven’t lost to Pisa at home in over eight consecutive encounters, this chance is more than realistic.
As for the visitors, after a relatively lively start to the campaign, Pisa are now spiraling into crisis. Three straight defeats without scoring, including losses to fellow strugglers Lecce and Parma, highlight their slump.
Their six-game unbeaten streak is a distant memory, and now the Nerazzurri are among the main relegation contenders. Pisa have yet to win away from home, and only four points collected on the road is far from the ambition of a club recently returned to Serie A after a long absence.
Probable lineups
- Cagliari: Caprile, Zappa, Mina, Luperto, Palestra, Adopo, Deiola, Folorunsho, Obert, Esposito, Borrelli
- Pisa: Semper, Calabresi, Caracciolo, Canestrelli, Toure, Vural, Aebischer, Marin, Angori, Moreo, Meister
Match facts and head-to-head
- Cagliari are unbeaten in their last eight home matches against Pisa.
- Pisa have failed to score in three consecutive games.
- Pisa’s last Serie A win over Cagliari dates back to October 1990.
Prediction
Cagliari have several factors working in their favor — home ground, a dominant head-to-head record, and a slightly more reliable attack. Given Pisa’s attacking woes and their total lack of away victories, a clean win for the hosts looks logical. The recommended bet: “Cagliari to win with handicap (0)” at 1.58 odds.
