Betis vs Lyon pronostic, H2H and probable lineups – 6 November 2025

Real Betis vs Lyon prediction Photo: dazn.com / Author unknown
Europa League (Round 4) 06 nov 2025, 15:00
Finished
2 : 0
International, Seville, Estadio de La Cartuja
Abdessamad Ezzalzouli
30'
Antony
35'

One of the matches of the fourth round of the 2025/26 UEFA Europa League group stage will take place on Thursday at the Benito Villamarín Stadium in Seville, where Betis will host French side Lyon. Let's take a closer look at a promising pick for the outcome of this encounter with solid chances of success.

Match preview

Betis are confidently navigating their group, having collected five points from three matches. The team plays pragmatic football, conceding few goals and making the most of every opportunity. A home draw against Nottingham Forest and an away win over Ludogorets prove that the Green-and-Whites approach each game with high concentration.

Recently, the team has been showing impressive attacking form: 10 goals in their last two outings, including a rout in the Cup and a convincing victory over Mallorca. The loss of Isco is significant, but key players like Antony are in top form and capable of driving the team forward.

Lyon are one of the few clubs to have started the group stage with three wins in a row, and they have yet to concede a single goal. The French side confidently dispatched Utrecht, Salzburg, and Basel, securing a spot among the group leaders. They consistently score in each half, dictating the tempo of the game.

Despite inconsistent performances in Ligue 1, Lyon have displayed a high level of organization and focus in the Europa League. Injuries among attacking players have somewhat limited their options, but the core of the squad operates cohesively. Even a draw in Seville would be considered an acceptable result for Les Gones.

Probable lineups

  • Betis: Vallés, Bellerín, Bartra, Nathan, Rodriguez, Amrabat, Fornals, Antony, Lo Celso, Ez Abde, Hernandez
  • Lyon: Greif, Tagliafico, Niahaté, Mata, Hateboer, Tessmann, Morton, Tolisso, M. Satriano, A. Moreira, Schulz

Match facts and head-to-head

  • Lyon have won all three group stage matches and have yet to concede a goal.
  • Betis are unbeaten in the Europa League and have lost just once in their last 11 matches in all competitions.
  • Both teams are currently in the top six of their respective domestic leagues.

Prediction

Lyon look like the more structured and stable side in European competition. Despite being away from home, the French outfit play mature football and are worthy of trust. We believe Lyon can avoid defeat in this match.

Prediction on game Lyon wont lose
Odds: 1.93
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