Atletico vs Inter prediction, H2H and probable line-ups - November 26, 2025
One of the Champions League group stage clashes will take place on Wednesday at the Metropolitano Stadium in Madrid, where the local side Atletico will host Inter Milan. Let’s break down the odds and see which outcome offers the best value for this high-stakes encounter.
Match preview
Atletico head into this match riding an impressive five-game winning streak across all competitions, though their Champions League campaign has been a bit of a rollercoaster. The Rojiblancos have suffered two losses in England but picked up convincing home victories, including a 5-1 thrashing of Eintracht and a 3-1 win over Royale Union in the last round. On home turf, Atletico are a force to be reckoned with: they’ve lost just once in their last 16 European outings at the Metropolitano and have won 10 of the last 11 there.
However, they have yet to secure qualification to the next stage, making this clash with Inter absolutely crucial. Squad issues could complicate matters—both Llorente and Oblak are doubtful, and those are key players in Diego Simeone’s system. Still, the motivation and passionate home support could help offset these personnel problems.
Inter remain one of only three teams with a perfect record after four group stage matches, alongside Bayern and Arsenal. The Nerazzurri have won all four games, scoring at least twice in each. During this run, they’ve seen off Ajax, Slavia, Union SG, and Kairat, showing impressive consistency and quality. Domestically, however, there have been some stumbles—this autumn, Inter suffered defeats against Napoli, Juventus, and lost the Milan derby to AC Milan at the weekend.
But in the Champions League, Inter look like a different beast: the team maintains laser-sharp focus, as evidenced by 11 clean sheets in their last 13 European matches. Up front, Lautaro Martinez is the main man—he could make his 50th tournament appearance—and his partnership with Thuram is a constant threat. Despite a string of injuries, particularly down the right flank, the Italian club appear composed and determined to keep their perfect run alive.
Probable line-ups
- Atletico: Musso, Molina, Gimenez, Hanko, Ruggeri, Simeone, Barrios, Koke, Gonzalez, Sorloth, Alvarez
- Inter: Sommer, Akanji, Bisseck, Bastoni, Augusto, Barella, Calhanoglu, Zielinski, Dimarco, Martinez, Thuram
Match facts and head-to-head
- Atletico have won 10 of their last 11 Champions League home games.
- Inter have taken maximum points from their first four group stage matches.
- In their last head-to-head in 2024, Atletico knocked Inter out of the UCL in the playoffs on penalties.
Prediction
Both teams are packed with quality, but Inter have shown more consistency in Europe so far. Still, Atletico have the home advantage, which could prove decisive. Expect both sides to find the net in what should be a thrilling contest.
